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This has led some researchers to target 9mg rather than 12mg as their maintenance dose, especially given that the difference (2.3 percentage points) may not justify the additional side effect burden for all individuals

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Efficacy and safety of semaglutide 24mg once weekly in adults with overweight or obesity and type2 diabetes (STEP 2): A randomised, double-blind, double-dummy, placebo-controlled, phase 3 clinical trial

Instead, our findings demonstrate an important role for GSH in the liver, where under resting conditions, GSH maintains low NRF2 activity to permit ample expression of lipogenic enzymes, promotes the production of triglycerides, and sustains lipid abundance in vivo